Andoni Iraola makes two change to the Bournemouth side that drew 1-1 with Sunderland on Saturday.
Ryan Christie and Evanilson come into the side, with David Brooks and top scorer Eli Junior Kroupi dropping to the bench.
AFC Bournemouth: Petrovic, Jimenez, Hill, Senesi, Truffert, Adams, Scott, Rayan, Christie, Tavernier, Evanilson. Subs: Mandas, Brooks, Smith, Diakite, Adli, Junior Kroupi, Unal, Toth, Milosavljevic.
Brentford boss Keith Andrew makes three alterations to his side after their dramatic 4-3 win over Burnley three days ago.
Caoimhin Kelleher returns in goal after missing that game because of the birth of his child. Jordan Henderson comes into midfielder and Nathan Collins starts in defence.
Hakon Rafn Valdimarsson, Kristoffer Ajer, and Yehor Yarmoliuk drop to the bench.
Brentford: Kelleher, Kayode, Collins, van den Berg, Henry, Henderson, Jensen, Ouattara, Damsgaard, Schade, Thiago. Subs: Valdimarsson, Pinnock, Yarmolyuk, Ajer, Lewis-Potter, Donovan, Furo, Bentt, Shield.